Warning about vitamin B6

Vitamin B6 is often mentioned as help to be relieved from high histamine levels, due to it’s important role in the breakdown of histamine by DAO.

But I’d like to warn everybody, it is well-known that high dosages of vitamin B6 can lead to neurotoxicity, meaning that it kills of your nerves. What is less well-known is that even in lower dosages in can have detrimental effects on certain people. Which I experienced myself.  I started taking about 25 mg a day, within a view days my limbs would often get numb, just like you get a sleepy leg or arm every now and then, but this was worse. They’d fall asleep constantly whatever position I took, I started to get tired and dizzy. And before I knew it, I was laying in my bed trying to find a comfortable enough place not to be bothered by the constant tingling and sleepiness of my body, while trying to remain conscious. Didn’t really help that deadlines and exams were coming up.

Luckily for me, the effect didn’t last very long, as opposed to those people who get problems after taking high dosages  for a long time, but it was still very uncomfortable and highly disruptive of my life. During the time I was able to stay awake, I googled like crazy, trying to find out what was happening to me this time. I soon found out about the toxic effects of B6, and that it can also have nasty effects in lower dosages in certain people.  This can be due to a certain sensitivity in those people, but it can also come from a deficiency of other vitamin B’s and magnesium. Magnesium shouldn’t have been an issue, since I already supplement with magnesium. Maybe it was due to the lack of other vitamin’s, since well, I’ve stopped taking complete vitamins and complete vitamin b supplements. As these contain minerals and vitamins that can lead to a higher level of histamine and should be avoided in case of a histamine intolerance. Yes folic acid(B9), vitamin b12 and niacin(B3) I’m looking at you.

So instead I’ve started to eat more foods that contain high levels of vitamin B6, the daily dosage is only about 1 to 2 mg, and the melatonin I often take also contains a view mg, so does the energy drink I often indulge in. And yeah I know caffeine is bad, the weird chemicals in it are also bad. But I need my caffeine dose and sugar dose, and I just love to drink them. When I don’t drink too many too fast it doesn’t affect me all that much. Though coffee and green tea, which both contain caffeine can make me feel very sick.

So if you’ve started taking vitamin B6 and notice any side effects like numbness, dizziness and fatigue. Stop taking it!

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15 CommentsLeave a comment

  1. […] C can be taken in a dose ranging from 1000 to 5000 mg. Vitamin B, one should be careful with, see my warning about it, I wouldn’t recommend going above a dosage of 25 mg, as 1 to 2 mg is enough. […]

  2. Thank you for sharing your story and information. I truly appreciate it.

  3. Interesting reading. But i do not think that B6 aggravates histamine levels. Another function of b6 is rising the count of white blood cells, that take care of antigens. So better explanation of worseninng the symptoms after taking b6 may be the really high amount of antigens caused by some bacteria, virus or fungi.

  4. Thanks for the warning. I also experienced tingling and numbness in feet after taking about a third of a b6 over a few days time. Now I only take a small piece occasionally in hope that it may help increase DAO.I can’t take any vitamin b or high histamine foods either.

    • Its possible you may be TH2 then. Look it up when you get time.

  5. Looking forward to reading more. Great article.Thanks Again.

  6. B12 and folate don’t increase histamine, they lower it. In fact these two nutrients, are used by the body for proper methylation, which is one of the two ways the body deals with histamine.

    Note: Folic acid is synthetic folate, and should never be used. But active folates are great.

  7. Yes, stop it, though I didn’t know B6 is stored in the muscle. My feet numbness started over four years ago, but I was finally tested late Oct 2015 and learned the results, early Nov 2015, of B6 toxicity. Grrrrr. Four doctors, three neurologists and one rheumatologist never even thought to test B6 and chalked up the numbness/tingling/burning to a previous health diagnosis, multiple sclerosis.

    I was finally tested when I had the wherewithal to ask for the B6 test. Who knows if I’ll ever get back to normal and don’t have permanent nerve damage? Time will tell. Sigh….

    • Lind 7 how are You felling ..I have the same probl. I-am from România and the doctor never here about B6 been higher because IT is a hidrosolubil vitamina.How are You felling after stop the vitm b???

      • So sorry, Corina! I never answered you. It’s been 17 months now since I stopped the B6. I had labs 12/2016, and B6 is now within the range. I was concerned I went too low (deficiency), but have not. Hooray! I lime too many foods with B6.

        While my feet are still numb, there are times they nearly feel normal. I like that! Of course I found out my iron is ridiculously high… and the was even after donating blood twice. I donated late December 2016, and then again in February 2017. I have hopes that once this iron is where it should be, including ceruloplasmin, my RBCMag will improve. Maybe this is the year AND the B6 toxicity nerve damage will reverse.

        How are you? I hope to hear from you…. eventually! 🤗

  8. Muito interessante

  9. Perhaps switch to pyridoxal phosphate form of B6 instead of taking the peridoxine HCL (hydrochloride, which is an ACID). ‘Google’ pyridoxal phosphate for info.

  10. I wonder if your iron is high. High iron uses magnesium. I tested as B6 toxic, 11/2015; same time, all other B vitamins were elevated, too. I was taking magnesium, and of course, B-complex and B6 (P5P).

    Bad news is that I went four years complaining of numb feet, but never tested until I knew to ask. I complained to four different doctors, three neurologists and one rheumatologist. Grrrrrr.

    Found out my iron was high 12/2016; apparently it was not tested in 2015.

    12/2016 (& this was AFTER two prior blood donations!):
    SI Tot 226 (27-159)
    TIBC 317
    Sat% 71
    UIBC 91 (131-425)
    Ferritin 112
    RBC 5.24
    Hg 15.3
    Ht 45.6%
    Tot Bilir: 1.0 mg/dL(0-1.3)

    RESULTS 7/2017 (even after 3 blood donations):
    Iron, Total 175 (50-170)
    TIBC 335 (265-497)
    Iron Saturation 52% (15-50)
    Ferritin 48 (7-270)
    RBC 5.32 (3.80-5.10)
    HCT 47 (35-45)
    HGB 15.5 (11.7-15.5)

    Still getting the iron down… Feet feel a bit better, but definitely not 100%. Right arm and hand weakness since 2014—is it from the B6 toxicity? Maybe.

  11. just found your blog, beside I’m reading about histamine and related problems for about 2.5 years I find your contents to be full of new interesting pieces of the puzzle.

    I had your same experience with B6 and actually had your symptoms and beginning of nerve damages. I was popping 200 mg a day (plus other surces) of pyridoxine hcl…not even bothering to check as I was under the impressiin that not only the surplus would have been flushed but because b6 converts to many other substances like b3 etc the surplus would ended in producing more vital substances.

    1# mistake is about the form of B6…pyridoxine hcl that is actually the one proved to create nerve damage but also making impossible to absorb natural form of b6.
    2# mistake is about methylation….I was very low in B12 and methyl groups so b6 could not be processed into others substances.

    Now I’m steering away from any pyridoxine(basically all cheap integrators and fortified food)and I’m thinking to try again with pyridoxal because I truly enjoied the effects of b6.

    I’m interested to know about potential toxicity of pyridoxal and the safe dosing for someone with methylation deficency.

  12. Hi i am new here and recently experiencing histamine intolerance symptoms although it’s beeb going on for at least a year and I shrugged it off as food sensitivities …I’m struggling to maintain a healthy weight as I’m underweight to begin with and now with the restrictions on my diet I’ve lost at least 9 pounds and I’m becoming very depressed and scared ,, I have not been eating high histamine foods and still reacting I do have a significant amount of stress too which I know definitely contributes .. I was wondering about the supplements you have stated work , is there proof that it works ? With my histamine intolerance I am experiencing flushing on my face and hives on my face ( cheekbones) they last days and by the time the go away I get them back . I wake up with terrible headaches and my stomach hurts most days . 😦 I’m desperate for relief some days I’m so hopeless I have a child at home and I feel like this is such a bad situation, my life has been turned upside down and instead of being a mom I’m on the internet 24/7 looking for answers it’s devastating

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